Drug efflux transporter multidrug resistance-associated protein 5 affects sensitivity of pancreatic cancer cell lines to the nucleoside anticancer drug 5-fluorouracil.

@article{Nambaru2011DrugET,
  title={Drug efflux transporter multidrug resistance-associated protein 5 affects sensitivity of pancreatic cancer cell lines to the nucleoside anticancer drug 5-fluorouracil.},
  author={Praveen K Nambaru and Tobias Huebner and Kathleen Koeck and Steffen Mews and Markus Grube and L. A. Payen and J{\'e}r{\^o}me Guitton and Matthias Sendler and Gabriele Jedlitschky and Christian Rimmbach and Dieter Rosskopf and Dariusz W. Kowalczyk and Heyo Klaus Kroemer and Frank Ulrich Weiss and Julia Mayerle and Markus M. Lerch and Christoph Alexander Ritter},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2011},
  volume={39 1},
  pages={132-9}
}
Pancreatic adenocarcinoma is one of the malignancies that is highly resistant to therapy and among the leading causes of cancer-related death. Several factors may influence pancreatic cancer resistance, and expression of ATP-binding cassette transport proteins is one of the major mechanisms of drug resistance. Members of this family's C-branch, also referred to as multidrug resistance-associated proteins (MRPs), might be of particular interest because they are able to efflux nucleoside analogs… CONTINUE READING

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