Drug efflux mediated by the human multidrug resistance P-glycoprotein is inhibited by cell swelling.

@article{Sardini1994DrugEM,
  title={Drug efflux mediated by the human multidrug resistance P-glycoprotein is inhibited by cell swelling.},
  author={Alessandro Sardini and Gerard M Mintenig and M. A. Lopez Valverde and Francisco V Sep{\'u}lveda and Deborah Rebecca Gill and Stephen C. Hyde and Christopher F. Higgins and Peter A McNaughton},
  journal={Journal of cell science},
  year={1994},
  volume={107 ( Pt 12)},
  pages={3281-90}
}
P-glycoprotein (P-gp), the product of the human multidrug resistance (MDR1) gene, confers multidrug resistance on cells by acting as an ATP-dependent drug transporter. A method using confocal microscopy was developed to measure the transport activity of P-gp from the rate of movement of doxorubicin, a fluorescent substrate of P-gp, across the membrane of a single cell. Recent work has shown that expression of P-gp enhances the activation of chloride channels in response to cell swelling… CONTINUE READING

References

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Measurement of doxorubicin transport in single cells using confocal microscopy

A. Sardini, P. A. McNaughton
J . Physiol . • 1994

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