Drug effects on retinol oxidation: retinal alcohol:NAD+ oxidoreductase.


A spectrophotometric method was used to follow the oxidation of retinol by preparations of cattle retinas. Two-tenths millimole chlorpromazine (CPZ) and thioridazine (TRDZ) activated the initial rate. This was followed by inhibition. These effects are reversible. The ring sulfoxide of chlorpromazine and thioridazine thiomethyl sulfoxide (TPS-23) had no… (More)


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