Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios.

@article{Williams2004DrugdrugIF,
  title={Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios.},
  author={John A. Williams and R. W. Hyland and Barry C. Jones and Dennis A. Smith and Susan I Hurst and Theunis C. Goosen and Vincent C Peterkin and Jeffrey R. Koup and Simon E Ball},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2004},
  volume={32 11},
  pages={1201-8}
}
Glucuronidation is a listed clearance mechanism for 1 in 10 of the top 200 prescribed drugs. The objective of this article is to encourage those studying ligand interactions with UDP-glucuronosyltransferases (UGTs) to adequately consider the potential consequences of in vitro UGT inhibition in humans. Spurred on by interest in developing potent and selective inhibitors for improved confidence around UGT reaction phenotyping, and the increased availability of recombinant forms of human UGTs… CONTINUE READING
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