Drug distribution between blood and brain as a determinant of antipsychotic drug effects

@article{Tsuneizumi1992DrugDB,
  title={Drug distribution between blood and brain as a determinant of antipsychotic drug effects},
  author={Tomohiro Tsuneizumi and Suzann M. Babb and Bruce M Cohen},
  journal={Biological Psychiatry},
  year={1992},
  volume={32},
  pages={817-824}
}
  • Tomohiro Tsuneizumi, Suzann M. Babb, Bruce M Cohen
  • Published in Biological Psychiatry 1992
  • Psychology, Medicine
  • Concentrations of the neuroleptics haloperidol, bromperidol, fluphenazine, chlorpromazine and its metabolites nor-1- and nor-2-chlorpromazine, thioridazine and its metabolites mesoridazine, sulforidazine, and northioridazine, and promazine were estimated in serum and brain of rats by high performance liquid chromatography (HPLC) with electrochemical detection following 5 days of chronic administration of drug at typical doses (haloperidol, bromperidol, and fluphenazine 1 mg/kg/day… CONTINUE READING

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