Drug discrimination models in anxiety and depression.

  title={Drug discrimination models in anxiety and depression.},
  author={J. S. Andrews and D. N. Stephens},
  journal={Pharmacology & therapeutics},
  volume={47 2},
Drug discrimination is a technique for investigating the stimulus properties of centrally active drugs. Although many studies have employed animals to investigate the stimulus properties of substances used clinically for the treatment of anxiety and depression, it would be a mistake to consider the internal discriminative stimuli as being related specifically to the anxiolytic or antidepressant properties of these drugs. Rather drug cues are better considered as relating to the pharmacological… CONTINUE READING