Drug discrimination in methamphetamine-trained monkeys: effects of monoamine transporter inhibitors.

@article{Czoty2004DrugDI,
  title={Drug discrimination in methamphetamine-trained monkeys: effects of monoamine transporter inhibitors.},
  author={Paul W. Czoty and Chinnasamy Ramaraj Ramanathan and Nicole H. Mutschler and Alexandros Makriyannis and J. R. Bergman},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2004},
  volume={311 2},
  pages={720-7}
}
The involvement of brain monoamine systems in the discriminative stimulus effects of methamphetamine (MA) was studied in squirrel monkeys by evaluating the effects of differentially selective monoamine uptake inhibitors alone and in combination. In monkeys discriminating i.m. injections of 0.3 mg/kg MA from saline, methamphetamine (0.01-0.3 mg/kg), and dopamine transporter (DAT) inhibitors, including 1-[2-(bis(4-fluorophenyl)-methoxy)ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909; 1.0-17.8 mg… CONTINUE READING

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