Drug discrimination and neurochemical studies in α7 null mutant mice: tests for the role of nicotinic α7 receptors in dopamine release

@article{Quarta2008DrugDA,
  title={Drug discrimination and neurochemical studies in α7 null mutant mice: tests for the role of nicotinic α7 receptors in dopamine release},
  author={Davide Quarta and Christopher G. Naylor and Jacques Barik and Cathy Fernandes and Susan Wonnacott and Ian P. Stolerman},
  journal={Psychopharmacology},
  year={2008},
  volume={203},
  pages={399-410}
}
The nicotine discriminative stimulus has been linked to β2-containing (β2*) nicotinic receptors, with little evidence of a role for α7 nicotinic receptors, because nicotine discrimination was very weak in β2 null mutant mice but normal in α7 mutants. As both α7 and β2* nicotinic receptors have been implicated in nicotine-stimulated dopamine overflow, this study focused on the dopamine-mediated element in the nicotine stimulus by examining cross-generalisation between amphetamine and nicotine… CONTINUE READING

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