Drug discovery in academia.

  title={Drug discovery in academia.},
  author={Alan S. Verkman},
  journal={American journal of physiology. Cell physiology},
  volume={286 3},
  • Alan S. Verkman
  • Published 2004 in American journal of physiology. Cell physiology
Drug discovery and development is generally done in the commercial rather than the academic realm. Drug discovery involves target discovery and validation, lead identification by high-throughput screening, and lead optimization by medicinal chemistry. Follow-up preclinical evaluation includes analysis in animal models of compound efficacy and pharmacology (ADME: administration, distribution, metabolism, elimination) and studies of toxicology, specificity, and drug interactions. Notwithstanding… CONTINUE READING


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