Drug discovery for a new generation of covalent drugs.

Abstract

INTRODUCTION The design of target-specific covalent inhibitors is conceptually attractive because of increased biochemical efficiency through covalency and increased duration of action that outlasts the pharmacokinetics of the agent. Although many covalent inhibitors have been approved or are in advanced clinical trials to treat indications such as cancer… (More)
DOI: 10.1517/17460441.2012.688744

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