Drug discovery by dynamic combinatorial libraries

  title={Drug discovery by dynamic combinatorial libraries},
  author={Olof Ramstr{\"o}m and J Lehn},
  journal={Nature Reviews Drug Discovery},
Dynamic combinatorial chemistry is a recently introduced supramolecular approach that uses self-assembly processes to generate libraries of chemical compounds. In contrast to the stepwise methodology of classical combinatorial techniques, dynamic combinatorial chemistry allows for the generation of libraries based on the continuous interconversion between the library constituents. Spontaneous assembly of the building blocks through reversible chemical reactions virtually encompasses all… CONTINUE READING
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