Drug discovery and natural products: end of an era or an endless frontier?

@article{Li2009DrugDA,
  title={Drug discovery and natural products: end of an era or an endless frontier?},
  author={Jesse W-H Li and John C Vederas},
  journal={Science},
  year={2009},
  volume={325 5937},
  pages={
          161-5
        }
}
  • Jesse W-H Li, John C Vederas
  • Published in Science 2009
  • Business, Medicine
  • Historically, the majority of new drugs have been generated from natural products (secondary metabolites) and from compounds derived from natural products. During the past 15 years, pharmaceutical industry research into natural products has declined, in part because of an emphasis on high-throughput screening of synthetic libraries. Currently there is substantial decline in new drug approvals and impending loss of patent protection for important medicines. However, untapped biological resources… CONTINUE READING

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