Drug discovery: Playing dirty

@article{Frantz2005DrugDP,
  title={Drug discovery: Playing dirty},
  author={Simon T Frantz},
  journal={Nature},
  year={2005},
  volume={437},
  pages={942-943}
}
942 not as specific as its creators had thought. The drug works by attaching to a key part of an overactive protein that causes chronic myeloid leukaemia. In his lecture, Druker revealed that the drug also inhibits a second protein, known as the PDGF receptor. Sitting in the audience, Heinrich had a brainwave. At the time, he was working on a protein similar to PDGF called KIT. “We became interested in the idea that Gleevec could probably inhibit KIT as well,” he says. Working with a team led… CONTINUE READING
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