Drug diffusion front movement is important in drug release control from swellable matrix tablets.

@article{Colombo1995DrugDF,
  title={Drug diffusion front movement is important in drug release control from swellable matrix tablets.},
  author={P. -E. Colombo and Ruggero Bettini and Gina Massimo and Pier Luigi Catellani and Patrizia Santi and Nicholas A Peppas},
  journal={Journal of pharmaceutical sciences},
  year={1995},
  volume={84 8},
  pages={991-7}
}
Swellable controlled release devices of buflomedil pyridoxalphosphate in hydroxypropyl methylcellulose were prepared, and their swelling and release behavior was investigated. The drug release as a function of time was investigated for various system parameters. Three distinct fronts were observed during the swelling and release processes, i.e., a swelling, a drug diffusion, and an erosion front. The drug diffusion front could be readily determined due to the drug's yellow color. The relative… CONTINUE READING

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