• DOI:10.1038/ncomms10638
Corpus ID: 14317455

Drug design from the cryptic inhibitor envelope

@article{Lee2016DrugDF,
  title={Drug design from the cryptic inhibitor envelope},
  author={C. Lee and Xiaofei Liang and Qinglin Wu and Javaria Najeeb and Jinshi Zhao and Ramesh Gopalaswamy and M. Tit{\'e}cat and F. Sebbane and N. Lema{\^i}tre and E. Toone and P. Zhou},
  journal={Nature Communications},
  year={2016},
  volume={7}
}

• C. Lee, Xiaofei Liang, +8 authors P. Zhou
• Published 2016
• Chemistry, Medicine
• Nature Communications

Conformational dynamics plays an important role in enzyme catalysis, allosteric regulation of protein functions and assembly of macromolecular complexes. Despite these well-established roles, such information has yet to be exploited for drug design. Here we show by nuclear magnetic resonance spectroscopy that inhibitors of LpxC—an essential enzyme of the lipid A biosynthetic pathway in Gram-negative bacteria and a validated novel antibiotic target—access alternative, minor population states in… Expand

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