Drug design at peptide receptors: somatostatin receptor ligands.

@article{Hannon2002DrugDA,
  title={Drug design at peptide receptors: somatostatin receptor ligands.},
  author={Jason P. Hannon and Caroline Nunn and Barbara Stolz and Christians Bruns and Gisbert Weckbecker and Ian Lewis and Thomas J. Troxler and Konstanze Hurth and Daniel Hoyer},
  journal={Journal of molecular neuroscience : MN},
  year={2002},
  volume={18 1-2},
  pages={15-27}
}
Somatostatin (SRIF, somatotropin release inhibiting factor), discovered for its inhibitory action on growth hormone (GH) secretion from pituitary, is an abundant neuropeptide. Two forms, SRIF14 and SRIF28 exist. Recently, a second family of peptides with very similar sequences and features was described; the cortistatins (CST), CST17 and CST29 which are brain selective. The five cloned SRIF receptors (sst1-5) belong to the G-protein coupled/ heptathelical receptor family. Structural and… CONTINUE READING
25 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

Similar Papers

Loading similar papers…