Drug design at peptide receptors: somatostatin receptor ligands.

  title={Drug design at peptide receptors: somatostatin receptor ligands.},
  author={Jason P. Hannon and Caroline Nunn and Barbara Stolz and Christians Bruns and Gisbert Weckbecker and Ian Lewis and Thomas J. Troxler and Konstanze Hurth and Daniel Hoyer},
  journal={Journal of molecular neuroscience : MN},
  volume={18 1-2},
Somatostatin (SRIF, somatotropin release inhibiting factor), discovered for its inhibitory action on growth hormone (GH) secretion from pituitary, is an abundant neuropeptide. Two forms, SRIF14 and SRIF28 exist. Recently, a second family of peptides with very similar sequences and features was described; the cortistatins (CST), CST17 and CST29 which are brain selective. The five cloned SRIF receptors (sst1-5) belong to the G-protein coupled/ heptathelical receptor family. Structural and… CONTINUE READING
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