Drug dependence as a disorder of neural plasticity: focus on dopamine and glutamate.

  title={Drug dependence as a disorder of neural plasticity: focus on dopamine and glutamate.},
  author={Luigi Pulvirenti and Marco Diana},
  journal={Reviews in the neurosciences},
  volume={12 2},
Drug addiction, as a disease, has grown to reach the level of a social illness. Psychostimulants, opiates, alcohol, nicotine and cannabis abuse affects millions worldwide and virtually all classes of modern society. In spite of the enormous proportions of its spread, intimate neurobiological mechanisms leading to distintictive features of this pathological status, such as craving for the abused substance and loss of control over intake, remain largely obscure and pharmacotherapies sadly… CONTINUE READING


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