Drug dependence and the endogenous opioid system

  title={Drug dependence and the endogenous opioid system},
  author={Mirjam Gerrits and Heidi M B Lesscher and Jan M van Ree},
  journal={European Neuropsychopharmacology},
The discovery of endogenous opioids has markedly influenced the research on the biology of drug dependence. Evidence has been presented that these brain substances are self-administered by laboratory animals. This finding, among others, has led to the hypothesis that endogenous opioids are involved in reinforcing habits, including dependence on drugs of abuse. The course of drug dependence is presented as a continuum from no drug use via controlled use to an actual dependence on the drug… CONTINUE READING


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