Drug dependence, a chronic medical illness: implications for treatment, insurance, and outcomes evaluation.

  title={Drug dependence, a chronic medical illness: implications for treatment, insurance, and outcomes evaluation.},
  author={A. Mclellan and D. C. Lewis and C. O’brien and H. Kleber},
  volume={284 13},
  • A. Mclellan, D. C. Lewis, +1 author H. Kleber
  • Published 2000
  • Medicine
  • JAMA
  • The effects of drug dependence on social systems has helped shape the generally held view that drug dependence is primarily a social problem, not a health problem. [...] Key Method A literature review compared the diagnoses, heritability, etiology (genetic and environmental factors), pathophysiology, and response to treatments (adherence and relapse) of drug dependence vs type 2 diabetes mellitus, hypertension, and asthma. Genetic heritability, personal choice, and environmental factors are comparably involved…Expand Abstract
    2,042 Citations

    Paper Mentions

    Interventional Clinical Trial
    The aim of this study is to determine the effect of continuation of buprenorphine/naloxone in patients with history of Opioid Use Disorder (OUD) scheduled for surgery compared to reduced… Expand
    ConditionsOpioid-use Disorder, Pain, Acute, Surgery
    Interventional Clinical Trial
    While substance use disorders have been found to have relapse rates on part with other chronic illnesses such as hypertension and asthma long term abstinence remains elusive for… Expand
    ConditionsOpioid Use
    Five-Year Recovery: A New Standard for Assessing Effectiveness of Substance Use Disorder Treatment.
    • 23
    Emerging approaches to managing alcohol dependence.
    • R. Swift
    • Medicine
    • American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
    • 2007
    • 33
    Drug dependence as a chronic medical illness.
    • 71
    • PDF
    Pharmacological treatment of alcohol dependence: target symptoms and target mechanisms.
    • 346
    Addiction, Co-morbidity and Chronic Disease Management
    • 3
    • PDF
    Substance Use Disorder: Biological Mechanisms, Clinical Effects and Neuroadaptations
    Pharmacotherapy of alcohol dependence: past, present and future research.
    • 7


    Genetic and environmental influences on drug use and abuse/dependence in male and female twins.
    • 225
    • PDF
    Drug dependence: stress and dysregulation of brain reward pathways.
    • 594
    Pharmacologic Treatment of Heroin-Dependent Patients
    • 164
    • PDF
    Alcohol and drug problems among diverse health and social service populations.
    • 113
    Genetic influences on DSM-III-R drug abuse and dependence: a study of 3,372 twin pairs.
    • 416
    The long-term course of treated alcoholism: II. Predictors and correlates of 10-year functioning and mortality.
    • 108
    Substance Abuse: A Comprehensive Textbook
    • 1,008
    • Highly Influential
    Common genetic vulnerability for nicotine and alcohol dependence in men.
    • 439
    • PDF
    Similarity of outcome predictors across opiate, cocaine, and alcohol treatments: role of treatment services.
    • 381
    One‐Year Follow‐Up Status of Treatment‐Seeking Cocaine Abusers: Psychopathology and Dependence Severity as Predictors of Outcome
    • 272