Drug dependence, a chronic medical illness: implications for treatment, insurance, and outcomes evaluation.

  title={Drug dependence, a chronic medical illness: implications for treatment, insurance, and outcomes evaluation.},
  author={A. Mclellan and D. C. Lewis and C. O’brien and H. Kleber},
  volume={284 13},
  • A. Mclellan, D. C. Lewis, +1 author H. Kleber
  • Published 2000
  • Medicine
  • JAMA
  • The effects of drug dependence on social systems has helped shape the generally held view that drug dependence is primarily a social problem, not a health problem. [...] Key Method A literature review compared the diagnoses, heritability, etiology (genetic and environmental factors), pathophysiology, and response to treatments (adherence and relapse) of drug dependence vs type 2 diabetes mellitus, hypertension, and asthma. Genetic heritability, personal choice, and environmental factors are comparably involved…Expand Abstract
    2,019 Citations

    Paper Mentions

    The aim of this study is to determine the effect of continuation of buprenorphine/naloxone in patients with history of Opioid Use Disorder (OUD) scheduled for surgery compared to reduced… Expand
    ConditionsOpioid-use Disorder, Pain, Acute, Surgery
    While substance use disorders have been found to have relapse rates on part with other chronic illnesses such as hypertension and asthma long term abstinence remains elusive for… Expand
    ConditionsOpioid Use
    Five-Year Recovery: A New Standard for Assessing Effectiveness of Substance Use Disorder Treatment.
    • 23
    Drug dependence as a chronic medical illness.
    • 66
    • PDF
    Emerging approaches to managing alcohol dependence.
    • R. Swift
    • Medicine
    • American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
    • 2007
    • 34
    Addiction, Co-morbidity and Chronic Disease Management
    • 3
    • PDF
    Chronic care management for dependence on alcohol and other drugs: the AHEAD randomized trial.
    • 95
    • PDF
    Pharmacological treatment of alcohol dependence: target symptoms and target mechanisms.
    • 343
    Pharmacotherapy of alcohol dependence: past, present and future research.
    • 7


    Genetic and environmental influences on drug use and abuse/dependence in male and female twins.
    • 222
    • PDF
    Drug dependence: stress and dysregulation of brain reward pathways.
    • 590
    Pharmacologic Treatment of Heroin-Dependent Patients
    • 163
    • PDF
    Alcohol and drug problems among diverse health and social service populations.
    • 112
    Genetic influences on DSM-III-R drug abuse and dependence: a study of 3,372 twin pairs.
    • 414
    Substance Abuse: A Comprehensive Textbook
    • 1,002
    • Highly Influential
    The long-term course of treated alcoholism: II. Predictors and correlates of 10-year functioning and mortality.
    • 108
    Common genetic vulnerability for nicotine and alcohol dependence in men.
    • 437
    • PDF
    Similarity of outcome predictors across opiate, cocaine, and alcohol treatments: role of treatment services.
    • 379
    One‐Year Follow‐Up Status of Treatment‐Seeking Cocaine Abusers: Psychopathology and Dependence Severity as Predictors of Outcome
    • 272