Drug delivery with carbon nanotubes for in vivo cancer treatment.

  title={Drug delivery with carbon nanotubes for in vivo cancer treatment.},
  author={Zhuang Liu and Kai Jen Chen and Corrine R. Davis and Sarah C. Sherlock and Qizhen Cao and Xiaoyuan Chen and Hongjie Dai},
  journal={Cancer research},
  volume={68 16},
Chemically functionalized single-walled carbon nanotubes (SWNT) have shown promise in tumor-targeted accumulation in mice and exhibit biocompatibility, excretion, and little toxicity. Here, we show in vivo SWNT drug delivery for tumor suppression in mice. We conjugate paclitaxel (PTX), a widely used cancer chemotherapy drug, to branched polyethylene glycol chains on SWNTs via a cleavable ester bond to obtain a water-soluble SWNT-PTX conjugate. SWNT-PTX affords higher efficacy in suppressing… CONTINUE READING
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