Drug delivery to the brain by focused ultrasound induced blood-brain barrier disruption: quantitative evaluation of enhanced permeability of cerebral vasculature using two-photon microscopy.

@article{Nhan2013DrugDT,
  title={Drug delivery to the brain by focused ultrasound induced blood-brain barrier disruption: quantitative evaluation of enhanced permeability of cerebral vasculature using two-photon microscopy.},
  author={Tam Le Nhan and Alison Burgess and Eunice E. Cho and Bojana Stefanovic and Lothar Lilge and Kullervo Hynynen},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2013},
  volume={172 1},
  pages={
          274-280
        }
}
Reversible and localized blood-brain barrier disruption (BBBD) using focused ultrasound (FUS) in combination with intravascularly administered microbubbles (MBs) has been established as a non-invasive method for drug delivery to the brain. Using two-photon fluorescence microscopy (2 PFM), we imaged the cerebral vasculature during BBBD and observed the extravasation of fluorescent dye in real-time in vivo. We measured the enhanced permeability upon BBBD for both 10 kDa and 70 kDa dextran… CONTINUE READING
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