Drug delivery systems: water soluble taxol 2'-poly(ethylene glycol) ester prodrugs-design and in vivo effectiveness.

@article{Greenwald1996DrugDS,
  title={Drug delivery systems: water soluble taxol 2'-poly(ethylene glycol) ester prodrugs-design and in vivo effectiveness.},
  author={Richard B. Greenwald and Carl W. Gilbert and Annapurna Pendri and Charles D. Conover and Jing Xia and A. Mart{\'i}nez},
  journal={Journal of medicinal chemistry},
  year={1996},
  volume={39 2},
  pages={
          424-31
        }
}
Water soluble 2'-taxol poly(ethylene glycol) (PEG) esters have been synthesized and shown to function in vitro as prodrugs. However, in vivo experiments clearly establish that in order for these prodrugs to behave in a predictable fashion, the molecular weight of PEG must be of such magnitude so as to maintain a t1/2(circulation) > t1/2(hydrolysis). When PEG derivatives of molecular weight approximately 40 kDa were employed with paclitaxel, ca. 4% by weight of paclitaxel was carried by the… 
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