Drug delivery strategy utilizing conjugation via reversible disulfide linkages: role and site of cellular reducing activities.

@article{Saito2003DrugDS,
  title={Drug delivery strategy utilizing conjugation via reversible disulfide linkages: role and site of cellular reducing activities.},
  author={Go Saito and Joel A Swanson and K D Lee},
  journal={Advanced drug delivery reviews},
  year={2003},
  volume={55 2},
  pages={199-215}
}
The first disulfide linkage-employing drug conjugate that exploits the reversible nature of this unique covalent bond was recently approved for human use. Increasing numbers of drug formulations that incorporate disulfide bonds have been reported, particularly in the next generation macromolecular pharmaceuticals. These are designed to exploit differences in the reduction potential at different locations within and upon cells. The recent characterization of a novel redox enzyme in endosomes and… CONTINUE READING

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