Drug delivery routes in skin: a novel approach.

  title={Drug delivery routes in skin: a novel approach.},
  author={Brian W. Barry},
  journal={Advanced drug delivery reviews},
  volume={54 Suppl 1},
The role of hair follicles in transdermal delivery remains difficult to elucidate due partly to animal model complications. This paper explores a novel technique employing two human skin membranes to differentiate shunt route delivery from bulk transepidermal input. The method monitors penetration through epidermal membranes and compares this with delivery through a sandwich of stratum corneum and epidermis, with the corneum forming a top membrane. As orifices of shunts occupy only 0.1% of the… CONTINUE READING

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