Drug delivery matrices based on scleroglucan/alginate/borax gels.

  title={Drug delivery matrices based on scleroglucan/alginate/borax gels.},
  author={Pietro Matricardi and Ilenia Onorati and Tommasina Coviello and Franco Alhaique},
  journal={International journal of pharmaceutics},
  volume={316 1-2},
The aim of this work is to obtain a new drug delivery matrix, especially designed for protein delivery, based on biodegradable and biocompatible polymers, and to describe its main physico-chemical properties. A polysaccharide based semi-interpenetrating polymer network (semi-IPN) was built up, composed by sodium alginate chains interspersed into a scleroglucan/borax hydrogel network. Tablets were obtained by compression of the resulting freeze-dried hydrogel. The different release and physico… CONTINUE READING