Drug delivery in overcoming the blood–brain barrier: role of nasal mucosal grafting

@inproceedings{Marianecci2017DrugDI,
  title={Drug delivery in overcoming the blood–brain barrier: role of nasal mucosal grafting},
  author={Carlotta Marianecci and Federica Rinaldi and Patrizia N Hanieh and Luisa Di Marzio and Donatella Paolino and Maria Carafa},
  booktitle={Drug design, development and therapy},
  year={2017}
}
The blood-brain barrier (BBB) plays a fundamental role in protecting and maintaining the homeostasis of the brain. For this reason, drug delivery to the brain is much more difficult than that to other compartments of the body. In order to bypass or cross the BBB, many strategies have been developed: invasive techniques, such as temporary disruption of the BBB or direct intraventricular and intracerebral administration of the drug, as well as noninvasive techniques. Preliminary results, reported… CONTINUE READING
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