Drug concentration heterogeneity facilitates the evolution of drug resistance.

  title={Drug concentration heterogeneity facilitates the evolution of drug resistance.},
  author={Thomas B. Kepler and Alan S. Perelson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={95 20},
Pathogenic microorganisms use Darwinian processes to circumvent attempts at their control through chemotherapy. In the case of HIV-1 infection, in which drug resistance is a continuing problem, we show that in one-compartment systems, there is a relatively narrow window of drug concentrations that allows evolution of resistant variants. When the system is enlarged to two spatially distinct compartments held at different drug concentrations with transport of virus between them, the range of… CONTINUE READING


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