Drug-associated renal dysfunction and injury

@article{Choudhury2006DrugassociatedRD,
  title={Drug-associated renal dysfunction and injury},
  author={Devasmita Choudhury and Ziauddin Ahmed},
  journal={Nature Clinical Practice Nephrology},
  year={2006},
  volume={2},
  pages={80-91}
}
Renal dysfunction and injury secondary to medications are common, and can present as subtle injury and/or overt renal failure. Some drugs perturb renal perfusion and induce loss of filtration capacity. Others directly injure vascular, tubular, glomerular and interstitial cells, such that specific loss of renal function leads to clinical findings, including microangiopathy, Fanconi syndrome, acute tubular necrosis, acute interstitial nephritis, nephrotic syndrome, obstruction, nephrogenic… 

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References

SHOWING 1-10 OF 106 REFERENCES
The pathophysiology of acute renal failure.
Interstitial nephritis, the nephrotic syndrome, and chronic renal failure secondary to nonsteroidal anti-inflammatory drugs.
TLDR
Case-control studies suggest that patients at risk are older men who suffer from chronic heart disease and renal hypoperfusion, who may develop papillary necrosis, chronic interstitial nephritis, or even ESRD.
NSAIDs and kidney.
TLDR
In patients on long term NSAIDs without acute or chronic renal failure, subclinical renal dysfunction such as reduced creatinine clearance and impaired urine concentrating ability has been shown to be present and this sub-clinical dysfunction is reversible on withdrawal of NSAIDs, some reports have suggested a persistent residual dysfunction.
Anticancer Drug—Induced Kidney Disorders
TLDR
The incidence, presentation, prevention and management of anticancer drug-induced renal dysfunction is reviewed and clinical signs of nephrotoxicity and methods used to assess renal function are discussed.
Low fractional excretion of sodium with contrast media-induced acute renal failure.
TLDR
The findings raise the possibility that acute renal failure secondary to contrast media may be mediated either by decreases in renal perfusion or by acute tubular obstruction.
Antiviral drug-induced nephrotoxicity.
TLDR
The pathogenesis of antiviral drug-induced kidney injury, common nephrotoxic renal syndromes, and strategies for preventing kidney injury are reviewed.
New pharmacological protocols to prevent or reduce contrast media nephropathy.
TLDR
Recommendations to prevent contrast-associated nephrotoxicity are: 1) periprocedural hydration, 2) use of a low osmolality contrast, and 3) limiting the amount of contrast agent.
Biologic markers for the early detection of acute kidney injury
TLDR
The search for new biomarkers for acute kidney injury is evolving rapidly with advancement in modern technologies and with better biomarkers the authors will have the ability to detect injury earlier, identify subclinical injury, provide prognostic information on the course of renal impairment, identify the nephron segments most affected, and screen patients at risk for renal injury.
Contrast-associated nephropathy.
  • G. Porter
  • Medicine
    The American journal of cardiology
  • 1989
Acute renal failure and interstitial nephritis in a patient treated with rofecoxib: case report and review of the literature.
TLDR
A case of acute renal failure due to severe interstitial nephritis in a young woman treated with rofecoxib, a selective COX-2 inhibitor is described, illustrating the potential for similar renal adverse effects in both selective and nonselective COX inhibitors.
...
1
2
3
4
5
...