Drug-associated non-pyrogenic hyperthermia: a narrative review

  title={Drug-associated non-pyrogenic hyperthermia: a narrative review},
  author={Koen Sebastiaan Bongers and Mohammed Saji Salahudeen and Gregory Mark Peterson},
  journal={European Journal of Clinical Pharmacology},
Purpose Hyperthermia occurs when heat accumulation surpasses the body’s ability for heat dissipation. Many drugs may affect thermoregulation. This narrative review aimed to provide an overview of the current literature concerning reports of drug-associated non-pyrogenic hyperthermia. Methods A comprehensive search was performed across 5 databases covering the period of inception to March 2019, for publications that reported hyperthermia associated with drug use. Studies that reported potential… 

Drug‐associated hyperthermia: A longitudinal analysis of hospital presentations

This study aimed to examine hospitalizations and emergency department presentations due to hyperthermia and to investigate the potential association with drug therapy.

Antipsychotic Medication-Induced Hyperthermia Leading to Cerebrovascular Accident: A Case Report

Patients who are prescribed antipsychotics should be aware of the potentially fatal adverse events that can occur from these medications, and Thermoregulation may be impaired in these patients, resulting in significant hyperthermia, in which case antipsychotic medications should be discontinued.

Global warming, heat-related illnesses, and the dermatologist

The Effect of Heat Acclimatization, Heat Acclimation, and Intermittent Exercise on Aerobic Performance

This review concludes with a discussion of the methodology and results that led to the publication of this book and a review of the text itself.



Management of drug-induced hyperthermia>

Although the recognition of causative agents is increasing, the treatment of drug-induced hyperthermia remains unchanged and continues to be primarily supportive.

Diagnosis and treatment of drug-induced hyperthermia.

  • M. MusselmanS. Saely
  • Medicine
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
  • 2013
DIH is a hypermetabolic state caused by medications and other agents that alter neurotransmitter levels, and the treatment of DIH syndromes includes supportive care and pharmacotherapy as appropriate.

Influence of Drug Use on Morbidity and Mortality in Heatstroke

Drugs that impair thermoregulation are frequently encountered in patients admitted for heatstroke, and patients taking such drugs may experience increased morbidity over those patients not takingsuch drugs.

The heat is on: Molecular mechanisms of drug-induced hyperthermia

This review will briefly summarize mechanisms of thermoregulation and provide a survey of pharmacologic agents that can lead to hyperthermia and provide an overview of the established and candidate molecular mechanisms that regulate the actual thermogenic processes in heat effector organs BAT and SKM.

Heat-related illness.

Initial treatments should focus on lowering core temperature through cold water immersion, and Hyperthermia and central nervous system symptoms should prompt an evaluation for heat stroke.

Drug Fever

Investigation of which drugs were associated with drug fever reported from 1986 to 2007 found antibacterials remain the major class of drugs responsible for DF.

Drug Fever: a descriptive cohort study from the French national pharmacovigilance database.

Investigation of which drugs were associated with drug fever reported from 1986 to 2007 found antibacterials remain the major class of drugs responsible for DF.

Drug-induced hyperthermia in critical care

A review of the common classes of drugs that can induce hyperthermia, highlighting the deleterious effects of a sustained high temperature and outlining available treatments is outlined.

Heat stroke

The effectiveness of cooling devices, drugs, and therapies in heat stroke remains inconclusive and further large studies are required to continue to evaluate these treatment strategies.