Drug and Tracer Kinetics

  title={Drug and Tracer Kinetics},
  author={Jordan L. Holtzman},

Putting (single-cell) data into orbit

This work aims at applying the qualitative theory of dynamical systems to describe the differentiation process of cytoskeletal tubulines in single-cell mRNA sequencing by looking for a two-dimensional continuous time, autonomous dynamical system of polynomial type.

DATforDCEMRI: An R Package for Deconvolution Analysis and Visualization of DCE-MRI Data

The R package DATforDCEMRI, a Deconvolution Analysis Tool for DCE-MRI contrast agent concentration vs. time data is described, which allows the user to perform kinetic deconvolution analysis and visualize/explore the resulting voxel-wise parametric maps and associated data.

Volume Turnover Kinetics of Fluid Shifts after Hemorrhage, Fluid Infusion, and the Combination of Hemorrhage and Fluid Infusion in Sheep

The model suggested that volume recruitment to the central compartment after hemorrhage was primarily achieved by mechanisms other than volume equilibration between the two model compartments, which caused fluid retention, which expanded the tissue compartment.

Pharmacokinetics and Metabolism of Liposome-Encapsulated 2,4,6-Trihydroxygeranylacetophenone in Rats Using High-Resolution Orbitrap Liquid Chromatography Mass Spectrometry

A sensitive LC-HRMS method was developed and validated to quantify tHGA in rat plasma and showed good linearity (0.5–80 ng/mL), and the accuracy and precision were within 10%.

Innovative first order elimination kinetics working model for easy learning

First order elimination kinetics is easily understood with the help of above working model, which was developed from household waste materials like thermocol sheets, coke bottles, waste water pipe, colour etc.

Modeling energy intake by adding homeostatic feedback and drug intervention

A model with the capability to capture physiological counter-regulatory feedback actions triggered by energy imbalances is described, which may qualitatively explain differences in rate and extent of adaptation in observed EI and its concomitants in both rodents and humans.

Paul allergy : a report from the Children ' s Oncology Group asparaginase achieves therapeutic activity after pegaspargase Erwinia

This paper aims to provide a history of lymphoid Neoplasia in young children using a database of articles from the Pediatric Hematology and Free Research articles published in Bloodjournal.org between 1991 and 2002.

Erwinia asparaginase achieves therapeutic activity after pegaspargase allergy: a report from the Children's Oncology Group.

Erwinia asparaginase administered with this schedule achieved therapeutic NSAA at both 48 and 72 hours and was well tolerated with no reports of hemorrhage, thrombosis, or death, and few cases of grade 2 to 3 allergic reaction.

Flip-flop pharmacokinetics--delivering a reversal of disposition: challenges and opportunities during drug development.

The purpose of this article is to analyze both the pharmacokinetic interpretation errors and opportunities underlying the presence of flip-flop pharmacokinetics during drug development.

Modelling of tolerance and rebound in normal and diseased rats

Nicotinic acid (NiAc)-induced changes in non-esterified fatty acids (NEFA) were used as a tool to investigate key determinants of tolerance and rebound in normal Sprague Dawley and in obese Zucker rats, a disease model of dyslipidaemia, and a mechanistically-based feedback model was able to tease out important information aboutolerance and rebound.