Drug and Reinforcement History as Determinants of the Response-Maintaining Effects of Quinpirole in the Rat

@article{Collins2007DrugAR,
  title={Drug and Reinforcement History as Determinants of the Response-Maintaining Effects of Quinpirole in the Rat},
  author={G. Collins and J. Woods},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2007},
  volume={323},
  pages={599 - 605}
}
  • G. Collins, J. Woods
  • Published 2007
  • Psychology, Medicine
  • Journal of Pharmacology and Experimental Therapeutics
The present study examined the effect of drug and reinforcement history on quinpirole-maintained responding in rats. Quinpirole (0.01, 0.032, or 0.1 mg/kg per injection) was assessed as a reinforcer in experimentally naive rats, as well as in rats trained to self-administer cocaine, remifentanil, ketamine, or food under a fixed ratio 1 schedule of reinforcement. Quinpirole failed to maintain responding in experimentally naive rats, or in ketamine- or food-trained rats. However, robust… Expand
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