Drug-activation of brain reward pathways.

@article{Wise1998DrugactivationOB,
  title={Drug-activation of brain reward pathways.},
  author={Roy A Wise},
  journal={Drug and alcohol dependence},
  year={1998},
  volume={51 1-2},
  pages={
          13-22
        }
}
  • R. Wise
  • Published 1 June 1998
  • Biology, Psychology
  • Drug and alcohol dependence

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The evidence presented in this chapter highlight the RAS as a neuromodulatory system of superior brain activities, and validate Angiotensin II involvement in amphetamine-induced alterations through AT1 receptor activation, which would be prominent candidates for pharmacological treatment in pathologies related to altered dopamine neurotransmission.

MORPHINE-INDUCED PLACE PREFERENCE: INTERACTIONS WITH NEUROTRANSMITTER SYSTEMS

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Neuronal Nicotinic Acetylcholine Receptors:Molecular Targets for Alcoholism andEthanol Reward: A Dissertation

It is shown, for the first time, that a specific nAChR subtype, those that contain the α4 subunit (α4*), mediate voluntary ethanol consumption and reward and further supports the hypothesis that α4* nA ChRs are molecular targets for alcohol cessation therapies.

The Mesolimbic Dopamine Reward Circuit in Depression

Impulse activity of midbrain dopamine neurons modulates drug-seeking behavior

Results show that inhibiting dopamine cell impulse activity, by activation of dopamine autoreceptors, reduces drug-seeking behavior, which suggests that the impulse activity of midbrain dopamine cells could be an important factor contributing to relapse.
...

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