Drug Treatment of Anxiety: A Controlled Study of Opipramol and Chlordiazepoxide

@article{Grosser1965DrugTO,
  title={Drug Treatment of Anxiety: A Controlled Study of Opipramol and Chlordiazepoxide},
  author={H H Grosser and Edward R. Ryan},
  journal={British Journal of Psychiatry},
  year={1965},
  volume={111},
  pages={134 - 141}
}
  • H. Grosser, E. Ryan
  • Published 1 February 1965
  • Psychology, Medicine
  • British Journal of Psychiatry
Following the introduction of imipramine hydrochloride as the first specific thymoleptic drug, further compounds related to the iminodibenzyl family were developed. One of these was an iminostilbene derivative with a piperazine sidechain: opipramol (Insidon, Geigy), which has the formula 4-[3-(5H-dibenzo[b,f] azepine-5-yl)-propyl]-1-(2-hydroxyethyl)-piperazine-dihydrochloride (Schindler and Blattner, 1961). The nucleus is almost identical to that of imipramine and the sidechain is identical to… 
A COMPARISON BETWEEN DIAZEPAM, DIXYRAZINE, OPRIPRAMOL AND PLACEBO IN ANXIETY STATES
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TLDR
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A Comparative Trial of Opipramol and Chlordiazepoxide in the Treatment of Anxiety
TLDR
Although opipramol appeared to give more relief of somatic anxiety, the difference was not statistically significant and the total number of side effects recorded was similar on both drugs although drowsiness occurred twice as frequently on chlordiazepoxide as it did on opipramsol.
A Comparative Trial of Insidon and Stelazine in the Treatment of Anxiety
TLDR
In a double-blind comparison of opipramol and trifluoperazine the symptom ‘anxiety’ was found to be statistically more improved in the opipramsol group of patients.
Specific modulation of sigma binding sites by the anxiolytic drug opipramol
TLDR
After subchronic treatment, opipramol significantly down-regulated σ2 but not σ1 sites, suggesting that effects at ρ2 sites are involved in the anxiolytic properties of opipramsol.
Part 1. Improvement criteria in drug trials with neurotic patients
SYNOPSIS Published drug trials with neurotic patients are surveyed and rating scales and other improvement criteria are tabulated and related to outcome. These findings are compared with the results
Part 2. Improvement criteria in drug trials with neurotic patients
TLDR
Several rating and self-rating methods are recommended which appear to be suitable for the measurement of changes in distress in drug trials with neurotic patients.
Benzodiazepines for generalised anxiety disorder (GAD)
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The results show that methaminodiazepoxide is an effective agent in the relief of anxiety in neurotic patients.
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A preparation of iminostilbene in good yield is described. The properties and some of the reactions of this compound are discussed.
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