Drug Therapy for Back Pain: Which Drugs Help Which Patients?

@article{Deyo1996DrugTF,
  title={Drug Therapy for Back Pain: Which Drugs Help Which Patients?},
  author={Richard A. Deyo},
  journal={Spine},
  year={1996},
  volume={21},
  pages={2840–2849}
}
  • R. Deyo
  • Published 15 December 1996
  • Medicine
  • Spine
Study Design A brief review of current literature and issues on drug therapy for low back pain. Objectives To identify current knowledge and future research needs related to drug therapy. Summary of Background Data Drug therapy is one of many possible treatment choices for symptom relief in patients with low back pain. The variety of drugs used suggests that there is no uniquely successful form of drug therapy. One reason for uncertainty and slow progress in this area is the limited quality of… 
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  • Medicine
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  • 2008
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References

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TLDR
The literature has not demonstrated that antidepressants are superior to placebos in improving low back pain or related problems, and further randomized controlled trials are needed to determine whether antidepressants are useful forLow back pain.
1986 Volvo Award in Clinical Sciences: Tricyclic Antidepressants for Chronic Low-Back Pain: Mechanisms of Action and Predictors of Response
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  • Psychology, Medicine
    Spine
  • 1986
TLDR
Patients with chronic low-back pain and depression were treated double blind with desipramine or doxepin; 60% of patients had significant pain relief and several patients had only pain or depression relief.
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TLDR
It is concluded that injecting methylprednisolone acetate into the facet joints is of little value in the treatment of patients with chronic low back pain.
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TLDR
Although the results are not conclusive, imipramine may possibly be useful in the treatment of chronic low back pain, especially so when it exists as a component of masked depression.
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  • R. Deyo
  • Medicine, Psychology
    JAMA
  • 1983
TLDR
Conservative therapies for low back pain entail expense, work loss, and risk of side effects, so valid trials supporting use of corsets, bed rest, transcutaneous nerve stimulation, and conventional traction were not found.
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TLDR
The importance and implications of placebo effects in pain treatment and research from the existing literature are estimated, with emphasis on their magnitude and duration, the conditions influencing them, and proposed explanations.
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TLDR
It is concluded that facet joint injection is a non-specific method of treatment and the good results depend on a tendency to spontaneous regression and to the psychosocial aspects of back pain.
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TLDR
Numerically, the use of Tofranil produced a marked improvement in pain and stiffness in patients with 'disc lesion only' diagnoses, whereas placebo did not produce an improvement, however, this observation was far from reaching statistical significance.
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