Drug Targeting by Solid Lipid Nanoparticles for Dermal Use

@article{SantosMaia2002DrugTB,
  title={Drug Targeting by Solid Lipid Nanoparticles for Dermal Use},
  author={Claudia Santos Maia and Wolfgang Mehnert and Martin Schaller and Hans C. Korting and Anja Gysler and Annekathrin Haberland and Monika Sch{\"a}fer-Korting},
  journal={Journal of Drug Targeting},
  year={2002},
  volume={10},
  pages={489 - 495}
}
Long term topical glucocorticoid treatment can induce skin atrophy by the inhibition of fibroblasts. We, therefore, looked for the newly developed drug carriers that may contribute to a reduction of this risk by an epidermal targeting. Prednicarbate (PC, 0.25%) was incorporated into solid lipid nanoparticles of various compositions. Conventional PC cream of 0.25% and ointment served for reference. Local tolerability as well as drug penetration and metabolism were studied in excised human skin… 
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References

SHOWING 1-10 OF 29 REFERENCES
Vitamin A loaded solid lipid nanoparticles for topical use: occlusive properties and drug targeting to the upper skin.
Vitamin A-loaded solid lipid nanoparticles for topical use: drug release properties.
Skin Penetration and Metabolism of Topical Glucocorticoids in Reconstructed Epidermis and in Excised Human Skin
TLDR
In vitro determination of the dermal 17-monoesters concentrations may allow the prediction of the atrophogenic risk in man and the inactivation of highly potent, but also cell toxic, 17- monoesters to almost inactive 21-congeners appears less important in the skin.
Solid lipid nanoparticles (SLN) : an alternative colloidal carrier system for controlled drug delivery
TLDR
Solid lipid nanoparticles of optimized composition proved to be physically stable during sterilization (autoclaving) and on long-term as aqueous dispersion as well as in vitro drug release over 5 weeks (prednisolone).
Nanoparticles and liposomes: a state of the art.
  • P. Speiser
  • Biology
    Methods and findings in experimental and clinical pharmacology
  • 1991
TLDR
In the future, the authors must find a possibility to deliver the correct dose of the drug precisely to the diseased target organs, tissues or cells of destination, without flooding the organism with massive drug doses.
Nanoparticles and liposomes: a state of the art.
TLDR
In the future, the authors must find a possibility to deliver the correct dose of the drug precisely to the diseased target organs, tissues or cells of destination, without flooding the organism with massive drug doses.
Solid lipid nanoparticles (SLN) for controlled drug delivery--drug release and release mechanism.
  • A. zur Mühlen, C. Schwarz, W. Mehnert
  • Chemistry, Biology
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 1998
Light and electron microscopic findings in human epidermis reconstructed in vitro upon topical application of liposomal tretinoin.
TLDR
The in vitro findings further corroborate the hypothesis that liposomal encapsulation can increase the benefit/risk ratio of an active compound applied to the skin.
Application of vesicles to rat skin in vivo: a confocal laser scanning microscopy study.
...
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