Drug Solubility: Importance and Enhancement Techniques

  title={Drug Solubility: Importance and Enhancement Techniques},
  author={Ketan T. Savjani and Anuradha K. Gajjar and Jignasa Ketan Savjani},
  booktitle={ISRN pharmaceutics},
Solubility, the phenomenon of dissolution of solute in solvent to give a homogenous system, is one of the important parameters to achieve desired concentration of drug in systemic circulation for desired (anticipated) pharmacological response. Low aqueous solubility is the major problem encountered with formulation development of new chemical entities as well as for the generic development. More than 40% NCEs (new chemical entities) developed in pharmaceutical industry are practically insoluble… CONTINUE READING
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