Drug Screen Targeted at Plasmodium Liver Stages Identifies a Potent Multistage Antimalarial Drug

@inproceedings{Cruz2012DrugST,
  title={Drug Screen Targeted at Plasmodium Liver Stages Identifies a Potent Multistage Antimalarial Drug},
  author={Filipa P. da Cruz and C{\'e}cilie Martin and Kathrin Buchholz and Mar{\'i}a Jos{\'e} Lafuente-Monasterio and T. Rodrigues and Birte Soennichsen and Rui Moreira and Francisco-Javier Gamo and Matthias Marti and Maria M Mota and Michael Hannus and Miguel Prud{\^e}ncio},
  booktitle={The Journal of infectious diseases},
  year={2012}
}
Plasmodium parasites undergo a clinically silent and obligatory developmental phase in the host's liver cells before they are able to infect erythrocytes and cause malaria symptoms. To overcome the scarcity of compounds targeting the liver stage of malaria, we screened a library of 1037 existing drugs for their ability to inhibit Plasmodium hepatic development. Decoquinate emerged as the strongest inhibitor of Plasmodium liver stages, both in vitro and in vivo. Furthermore, decoquinate kills… CONTINUE READING

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