Drug Promiscuity in PDB: Protein Binding Site Similarity Is Key

@inproceedings{Haupt2013DrugPI,
  title={Drug Promiscuity in PDB: Protein Binding Site Similarity Is Key},
  author={V. Joachim Haupt and Simone Daminelli and Michael Schr{\"o}der},
  booktitle={PloS one},
  year={2013}
}
Drug repositioning applies established drugs to new disease indications with increasing success. A pre-requisite for drug repurposing is drug promiscuity (polypharmacology) - a drug's ability to bind to several targets. There is a long standing debate on the reasons for drug promiscuity. Based on large compound screens, hydrophobicity and molecular weight have been suggested as key reasons. However, the results are sometimes contradictory and leave space for further analysis. Protein structures… CONTINUE READING

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Three representative examples , namely the anti - cancer drug methotrexate , the natural product quercetin and the anti - diabetic drug acarbose are discussed in detail .
Three representative examples , namely the anti - cancer drug methotrexate , the natural product quercetin and the anti - diabetic drug acarbose are discussed in detail .
Three representative examples , namely the anti - cancer drug methotrexate , the natural product quercetin and the anti - diabetic drug acarbose are discussed in detail .
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