Drug Profile: Synadrin

  title={Drug Profile: Synadrin},
  author={J. Eric Murphy},
  journal={Journal of International Medical Research},
  pages={204 - 209}
  • J. E. Murphy
  • Published 1 March 1973
  • Biology
  • Journal of International Medical Research
Synadrin (prenylamine lactate) is well established in the long-term management and prophylaxis of angina pectoris. It moderates the cardiac effects of sympathetic stimulation by decreasing the uptake of noradrenaline at the sympathetic nerve endings in the myocardium, and by slowing calcium transport through the endoplasmic reticulum. Extensive clinical investigation and usage has shown Synadrin to have beneficial effects in angina within a narrow dosage range and without frequent or… 
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Adverse Reactions to Calcium Antagonists
The pharmacodynamic effects of the calcium antagonists can be related to the diseases being treated, since indications range from otherwise healthy patients with hypertension and good left ventricular function, to those with compromised function from ischaemia (associated with angina or myocardial infarction) or from cardiomyopathy.
Prevention of adriamycin-induced cardiotoxicity by prenylamine: a pilot double blind study.
It is suggested that simultaneous administration of PNL may mitigate ADM cardiotoxicity, but larger trials are needed to draw definite conclusions.
The Role of Prenylamine in the Prevention of Adriamycin-Induced Cardiotoxicity. A Review of Experimental and Clinical Findings
The mechanisms of adriamycin-related cardiotoxicity, the effects of prenylamine and the benefit from combined treatment are discussed.
Precursor Medications as a Source of Methamphetamine and/or Amphetamine Positive Drug Testing Results
  • J. Cody
  • Biology, Medicine
    Journal of occupational and environmental medicine
  • 2002
A series of compounds referred to as “precursor” drugs that are metabolized by the body to amphetamine and/or methamphetamine lead to positive results for amphetamines even though neither amphetamine nor methamphetamine were used, a possibility that must be considered in the review of laboratory results.
Single- and multiple-dose pharmacokinetics of R-(−)- and S-(+)-prenylamine in man
Plasma protein binding differed between the two enantiomers, generally with a higher unbound fraction of the S-form, whereas analysis of the bound fractions showed that prenylamine was bound to different plasma proteins with inverse stereoselectivity.


Anti-anginal drugs
This review of studies on anti-anginal agents and their use in the anginal syndrome shows nitroglycerin to be unsurpassed in clinical effectiveness. It has a rapid onset of action. Its duration of
A 2-year study of the efficacy and tolerability of prenylamine in the treatment of angina pectoris
  • N. Cardoe
  • Medicine
    Postgraduate medical journal
  • 1970
Twelve out-patients with established angina pectoris who had previously participated in a double-blind trial of prenylamine lactate continued to record their daily anginal attack rate and glyceryl trinitrate consumption and it was confirmed that this was due to the administration of the drug, which was again shown to be significantly more effective than identical placebo in the prophylaxis of angina Pectoris.
Risk with -blocking in bronchial asthma.
The case is overstated by Professor Scott when he says that, in a patient without prolapse, vagmai hysterectomy takes no longer than a laparoscopy, that the patients are more mobile the following day and that compiications are fewer.
The Principles and Practice of Clinical Trials.
This book is aimed at students, new medical recruits to the pharmaceutical industry and clinicians involved in the assessment of drugs, and has many pluses but also some minuses, including the uneven quality and sometimes inappropriateness of various chapters.
Prenylamine lactate ('Synadrin') in patients with angina pectoris.
  • N. Cardoe
  • Biology
    The British journal of clinical practice
  • 1968
The Uptake and Storage of Noradrenaline in Sympathetic Nerves