Drug Oxidation by Cytochrome P450BM3 : Metabolite Synthesis and Discovering New P450 Reaction Types.

@article{Ren2015DrugOB,
  title={Drug Oxidation by Cytochrome P450BM3 : Metabolite Synthesis and Discovering New P450 Reaction Types.},
  author={Xinkun Ren and Jake A. Yorke and Emily G. Taylor and Ting Zhang and Weihong Zhou and Luet Lok Wong},
  journal={Chemistry},
  year={2015},
  volume={21 42},
  pages={15039-47}
}
There is intense interest in late-stage catalytic C-H bond functionalization as an integral part of synthesis. Effective catalysts must have a broad substrate range and tolerate diverse functional groups. Drug molecules provide a good test of these attributes of a catalyst. A library of P450BM3 mutants developed from four base mutants with high activity for hydrocarbon oxidation produced human metabolites of a panel of drugs that included neutral (chlorzoxazone, testosterone), cationic… CONTINUE READING