Drug Off-Target Effects Predicted Using Structural Analysis in the Context of a Metabolic Network Model


Recent advances in structural bioinformatics have enabled the prediction of protein-drug off-targets based on their ligand binding sites. Concurrent developments in systems biology allow for prediction of the functional effects of system perturbations using large-scale network models. Integration of these two capabilities provides a framework for evaluating… (More)
DOI: 10.1371/journal.pcbi.1000938


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