Drug Metabolism and Pharmacokinetics of Organosulfur Compounds from Garlic
@article{Gao2013DrugMA,
title={Drug Metabolism and Pharmacokinetics of Organosulfur Compounds from Garlic},
author={Cui Gao and Xiaoyan Jiang and Hai-na Wang and Zhongxi Zhao and Wei-hong Wang},
journal={Journal of Drug Metabolism and Toxicology},
year={2013},
volume={4},
pages={1-10}
}The medicinal activities of garlic organosulfur compounds identified include antitumor, antimicrobial, antifungal, antivirus, anti-atherosclerosis, blood lipids and sugar lowering, antithrombotic, anti-hypotension and immune modulation effects. These multi-targeted new agents may be especially promising since recently developed highly specific anti-cancer agents as well as other disease treatment drugs have failed to live up to the expectations. Despite more than one thousand articles have been…
44 Citations
Functioning of Organosulfur Compounds from Garlic (Allium sativum Linn) in Targeting Risk Factor-Mediated Atherosclerosis: A Cross Talk Between Alternative and Modern Medicine
- BiologyNatural Bio-active Compounds
- 2019
It is hypothesized that garlic and its OSCs could be beneficial in targeting proprotein convertase subtilisin/kexin type-9 (PCSK-9) and LDL-R pathway in order to treat and manage hypercholesterolemia especially for the patients facing inadequate lipid lowering with classical HMG-R inhibitors (statins) and statin intolerance.
Vegetable Organosulfur Compounds and their Health Promoting Effects.
- Chemistry, MedicineCurrent pharmaceutical design
- 2017
The mechanisms of action of organosulfur compounds have started to unravel, with promising results for further exploitation of these significant bioactive compounds in drug development and novel nutraceutical products.
Cancer Chemoprevention by Garlic - A Review
- Biology
- 2015
An attempt has been made to review current knowledge on molecular targets of cancer chemoprevention by OSC present in garlic, which are highly effective in affording protection against cancer.
Cancer Chemoprevention by Garlic-A Review
- Biology
- 2015
An attempt has been made to review current knowledge on molecular targets of cancer chemoprevention by OSC present in garlic, which are highly effective in affording protection against cancer.
Contemporary Formulations for Drug Delivery of Anticancer Bioactive Compounds.
- BiologyRecent patents on anti-cancer drug discovery
- 2019
The focus of recent research is not only to clarify the exact mechanisms of action and therapeutic effects, but also to answer the issue of suitable delivery systems that can transport sufficient doses of bioactive compounds to the desired target.
Significant inhibitory impact of dibenzyl trisulfide and extracts of Petiveria alliacea on the activities of major drug-metabolizing enzymes in vitro: An assessment of the potential for medicinal plant-drug interactions.
- Chemistry, MedicineFitoterapia
- 2016
Inhibitory Activities of Sulfur Compounds in Garlic Essential Oil against Alzheimer's Disease-Related Enzymes and Their Distribution in the Mouse Brain.
- ChemistryJournal of agricultural and food chemistry
- 2021
It is found that several sulfur compounds in GEO significantly inhibited AD-related enzymes and similar results were observed in the serum, suggesting that the organosulfur compounds were converted to allyl mercaptan or allyl methyl sulfide in the body.
Hyaluronic Acid-Based Nanocapsules as Efficient Delivery Systems of Garlic Oil Active Components with Anticancer Activity
- BiologyNanomaterials
- 2021
It was shown that the encapsulation inhibited the lysis of the red blood cell membrane (mainly for DADS) and interactions with serum or digestive track components, and the biological functions and anticancer activity of DADS and DATS were preserved after encapsulation.
References
SHOWING 1-10 OF 113 REFERENCES
Allyl sulfur compounds and cellular detoxification system: effects and perspectives in cancer therapy
- Biology, ChemistryAmino Acids
- 2010
Although additional studies are needed to identify the molecular targets and modes of action of these natural compounds, the allyl sulfur compounds can represent potential ideal agents in anticancer therapy, either alone or in association with other antitumor drugs.
Modulation of cytochrome P450 enzymes by organosulfur compounds from garlic.
- Medicine, BiologyFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association
- 2005
An Evidence-based Perspective of Allium Sativum (Garlic) for Cancer Patients
- Biology
- 2011
Results of the in vitro studies explain the mechanisms of action of garlic organosulfurs at the molecular level, which is a necessary step before their clinical use for cancer patients, and summarizes the current knowledge on molecular mechanisms of its anti-proliferative activity toward cancer cells.
Naturally Occurring Organic Sulfur Compounds: An Example of a Multitasking Class of Phytochemicals in Anti-Cancer Research
- Chemistry
- 2011
Allium plants, especially garlic (Allium sativum), have been cultivated since thousands of years all over the world not only as spicy food but also as medicinal plant. According to Block, the garlic…
An in vitro evaluation of human cytochrome P450 3A4 and P-glycoprotein inhibition by garlic.
- Biology, MedicineJournal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques
- 2001
In vitro findings demonstrate that garlic components can affect cytochrome P-450 2C, 2D and 3A mediated-metabolism of the isoforms studied and the safety and efficacy of conventional therapeutic products metabolized by the affected isozymes needs to be examined further under clinical settings.
Antimutagenic activity of organosulfur compounds from Allium is associated with phase II enzyme induction.
- Biology, ChemistryMutation research
- 2001
Modulation of rat hepatic cytochrome P-450 activity by garlic organosulfur compounds.
- Chemistry, BiologyNutrition and cancer
- 1996
To determine whether the variable potency of inhibition of CYP2E1 enzyme activity is related to chemopreventive efficacy of garlic sulfur compounds, three garlic compounds were administered to acetone-treated adult male Sprague-Dawley rats.
Chemoprevention of colon carcinogenesis by organosulfur compounds.
- Biology, MedicineCancer research
- 1993
Inhibition of AOM-induced colon carcinogenesis by anethole trithione and diallyl disulfide may be associated, in part, with increased activities of phase II enzymes such as GST, NAD(P)H-dependent quinone reductase, and UDP-glucuronosyl transferase in the liver and colon.
Ajoene (natural garlic compound): a new anti-leukaemia agent for AML therapy.
- Biology, MedicineLeukemia research
- 2004
Metabolism of the chemoprotective agent diallyl sulfide to glutathione conjugates in rats.
- Chemistry, BiologyChemical research in toxicology
- 1997
Results indicate that while DAS and DASO undergo extensive oxidation in vivo at the sulfur atom, the allylic carbon, and the terminal double bonds, CYP2E1 preferentially catalyzes oxidation of the sulfur atoms to form the sulfoxide and the sulfone (DASO and DasO2).