Drug Interactions with Tobacco Smoking

@article{Zevin1999DrugIW,
  title={Drug Interactions with Tobacco Smoking},
  author={S. Zevin and N. Benowitz},
  journal={Clinical Pharmacokinetics},
  year={1999},
  volume={36},
  pages={425-438}
}
  • S. Zevin, N. Benowitz
  • Published 1999
  • Medicine
  • Clinical Pharmacokinetics
  • Cigarette smoking remains highly prevalent in most countries. It can affect drug therapy by both pharmacokinetic and pharmacodynamic mechanisms. Enzymes induced by tobacco smoking may also increase the risk of cancer by enhancing the metabolic activation of carcinogens.Polycyclic aromatic hydrocarbons in tobacco smoke are believed to be responsible for the induction of cytochrome P450 (CYP) 1A1, CYP1A2 and possibly CYP2E1. CYP1A1 is primarily an extrahepatic enzyme found in lung and placenta… CONTINUE READING

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