Drug Interactions with Tobacco Smoking

@article{Zevin1999DrugIW,
  title={Drug Interactions with Tobacco Smoking},
  author={Shoshana Zevin and Neal L. Benowitz},
  journal={Clinical Pharmacokinetics},
  year={1999},
  volume={36},
  pages={425-438}
}
Cigarette smoking remains highly prevalent in most countries. It can affect drug therapy by both pharmacokinetic and pharmacodynamic mechanisms. Enzymes induced by tobacco smoking may also increase the risk of cancer by enhancing the metabolic activation of carcinogens.Polycyclic aromatic hydrocarbons in tobacco smoke are believed to be responsible for the induction of cytochrome P450 (CYP) 1A1, CYP1A2 and possibly CYP2E1. CYP1A1 is primarily an extrahepatic enzyme found in lung and placenta… 
Drug interactions with smoking.
  • L. Kroon
  • Medicine
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
  • 2007
PURPOSE The mechanisms for drug interactions with smoking and clinically significant pharmacokinetic and pharmacodynamic drug interactions with smoking are reviewed. SUMMARY Polycyclic aromatic
Cytochromes P450: Roles in the Biotransformation of Chemicals in Cigarette Smoke and Impact of Smoking Cessation on Concurrent Drug Therapy
TLDR
The impact of smoking and smoking cessation on therapy with toxic drugs that undergo CYP-mediated elimination is reviewed and dose reductions and close therapeutic monitoring for such drugs are recommended in patients who cease smoking.
Effect of nicotine on cytochrome P450 1A2 activity.
TLDR
The hypothesis that nicotine induces CYP1A2-mediated metabolism of caffeine to paraxanthine, a well-established probe reaction of CYP 1A2 activity in humans in vivo is tested.
Smoking in Patients Receiving Psychotropic Medications
TLDR
Clinicians should consider smoking as an important factor in the disposition of these drugs, as smoking can affect the pharmacokinetic and pharmacodynamic properties of many psychotropic drugs.
Effects of Cigarette Smoking on Metabolism and Effectiveness of Systemic Therapy for Lung Cancer
TLDR
Systemic therapy for lung cancer has a narrow therapeutic index such that small changes in plasma concentrations or exposure in smokers may result in suboptimal therapy and poor outcomes.
Impact of smoking on metabolic changes and effectiveness of drugs used for lung cancer.
  • F. Perlík
  • Medicine
    Central European journal of public health
  • 2020
TLDR
The evaluated studies show that continued smoking after lung cancer diagnosis is related to poor prognosis, reduced survival, risk of second primary malignancies, and increased cancer recurrence.
Metabolism and Disposition Kinetics of Nicotine
TLDR
Current knowledge about the metabolism and disposition kinetics of nicotine, some other naturally occurring tobacco alkaloids, and nicotine analogs that are under development as potential therapeutic agents are reviewed.
CYP1A2 and tobacco interaction: a major pharmacokinetic challenge during smoking cessation
TLDR
Pharmacologists can now adopt adaptive pharmacological approaches to complement patient-specific clinical information about smoking cessation by considering pharmacokinetic risk and establish an unprecedented list of CYP1A2 substrates that should guide in the care of patients initiating smoking cessation.
The ability of polycyclic aromatic hydrocarbons to alter physiological factors underlying drug disposition
TLDR
The pharmacokinetic properties of PAH, the possible mechanisms by which they can alter drug disposition, and specific examples are discussed.
Nicotine and Tobacco
TLDR
People who smoke, or people who stop smoking, may require dosage adjustments when using some medications including acetaminophen, caffeine, imipramine, oxazepam, pentazocine, propranolol, theophylline, insulin, adrenergic antagonists, and adrenergic agonists.
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