Drug Interactions with Paracetamol

@article{Toes2005DrugIW,
  title={Drug Interactions with Paracetamol},
  author={Maurice J Toes and Alison Linda Jones and Laurie F. Prescott},
  journal={American Journal of Therapeutics},
  year={2005},
  volume={12},
  pages={56-66}
}
Paracetamol (acetaminophen) is one of the most commonly used analgesic antipyretic drugs worldwide, and it is widely available by prescription and over the counter (OTC). Fortunately, few clinically significant drug interactions have been documented. There is probable potentiation of hepatotoxicity following an overdose from the paracetamol metabolite NAPQI by enzyme-inducing drugs. There is considerable controversy regarding the possible interaction with warfarin in its potential to increase… 
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References

SHOWING 1-10 OF 99 REFERENCES
Does Paracetamol Potentiate the Effects of Oral Anticoagulants?
TLDR
The potential interaction between oral anticoagulant drugs and paracetamol is an important unanswered question, due to the growing incidence of the concomitant use of these drugs and the possible bleeding implications.
The effect of paracetamol (acetaminophen) on fentanyl metabolism in vitro
  • D. Feierman
  • Medicine
    Acta anaesthesiologica Scandinavica
  • 2000
TLDR
This work has shown that paracetamol is also metabolized by the CYP3A family, with a Km that is nearly equal to therapeutic blood concentrations, and its potential interaction with fentanyl metabolism would be of great interest.
Sustained intake of paracetamol (acetaminophen) during oral anticoagulant therapy with coumarins does not cause clinically important INR changes: a randomized double‐blind clinical trial
TLDR
The sustained use of paracetamol during oral anticoagulant therapy in itself does not provoke clinically relevant INR changes, and any important INR rise will predominantly be the result of the illness necessitating the intake of this medication.
Concomitant overdosing of other drugs in patients with paracetamol poisoning.
TLDR
Concomitant overdosing of benzodiazepines or analgesics is frequent in patients admitted with paracetamol poisoning and is associated with more severe toxicity, whereas concomitant Overdosing of opioid analgesics was associated with less toxicity.
Paracetamol Toxicity: is Enzyme Induction Important?
A female patient receiving carbamazepine developed severe liver damage after an overdose of paracetamol. Antidotal therapy was not administered because her plasma paracetamol concentration was below
Lack of effect of paracetamol on the pharmacokinetics of chloramphenicol.
The effect of oral paracetamol (1 g) on the pharmacokinetics of oral chloramphenicol (500 mg) was examined in five adult male Zimbabwean patients with normal hepatic and renal function. No
Acetaminophen hepatotoxicity: potentiation by isoniazid.
  • J. Crippin
  • Medicine
    The American journal of gastroenterology
  • 1993
TLDR
Patients on isoniazid should use caution when taking acetaminophen since the potentially hepatotoxic effects may be amplified due to induction of the cytochrome P-450 system.
Inhibition of the metabolism of paracetamol by isoniazid.
TLDR
Two days after isoniazid was discontinued, paracetamol metabolism had returned to pre-isoniazid values, and there was no effect of isoniaZid on the non-oxidative pathways of par acetamol elimination.
Carbamazepine-Provoked Hepatotoxicity and Possible Aetiopathological Role of Glutathione in the Events
  • M. Kalapos
  • Medicine
    Adverse drug reactions and toxicological reviews
  • 2002
TLDR
An epidemiological study of carbamazepine-induced hepatic injuries and death is presented, and the possible mechanisms of its toxicity are described.
The effect of acetaminophen on zidovudine metabolism in HIV-infected patients.
The concomitant administration of acetaminophen to HIV-positive patients receiving zidovudine (AZT) therapy has previously been thought to increase the likelihood of the toxicity of AZT due to
...
1
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4
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