Drug Interactions with Clinafloxacin

@article{Randinitis2001DrugIW,
  title={Drug Interactions with Clinafloxacin},
  author={Edward J. Randinitis and Christine W. Alvey and Jeffery R. Koup and George Rausch and Robert B. Abel and Nicola J. Bron and Neil J. Hounslow and Artemios B. Vassos and Allen J. Sedman},
  journal={Antimicrobial Agents and Chemotherapy},
  year={2001},
  volume={45},
  pages={2543 - 2552}
}
ABSTRACT Many fluoroquinolone antibiotics are inhibitors of cytochrome P450 enzyme systems and may produce potentially important drug interactions when administered with other drugs. Studies were conducted to determine the effect of clinafloxacin on the pharmacokinetics of theophylline, caffeine, warfarin, and phenytoin, as well as the effect of phenytoin on the pharmacokinetics of clinafloxacin. Concomitant administration of 200 or 400 mg of clinafloxacin reduces mean theophylline clearance by… 
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