Drug Interaction Between Clopidogrel and Ranitidine or Omeprazole in Stable Coronary Artery Disease: A Double-Blind, Double Dummy, Randomized Study.

@article{Furtado2016DrugIB,
  title={Drug Interaction Between Clopidogrel and Ranitidine or Omeprazole in Stable Coronary Artery Disease: A Double-Blind, Double Dummy, Randomized Study.},
  author={Remo Holanda de Mendonça Furtado and Robert P Giugliano and C{\'e}lia Maria C{\'a}ssaro Strunz and Cyrillo Cavalheiro Filho and Jos{\'e} Ant{\^o}nio Franchini Ramires and Roberto Kalil Filho and Pedro Alves Lemos Neto and Alexandre da Costa Pereira and Tania Rubia Flores da Rocha and Beatriz Tonon Freire and {\'E}lbio Ant{\^o}nio D'Amico and Jos{\'e} Carlos Nicolau},
  journal={American journal of cardiovascular drugs : drugs, devices, and other interventions},
  year={2016},
  volume={16 4},
  pages={275-84}
}
BACKGROUND Proton-pump inhibitors (PPIs) are often prescribed to patients receiving dual antiplatelet therapy (DAPT). However, this class of medication, especially omeprazole, has been associated with a reduction in clopidogrel efficacy, leading many clinicians to substitute omeprazole with ranitidine. OBJECTIVES Our objective was to compare the antiplatelet effect of clopidogrel before and after the addition of omeprazole or ranitidine. METHODS We measured platelet aggregability at… CONTINUE READING