Drug Insight: rituximab in renal disease and transplantation

  title={Drug Insight: rituximab in renal disease and transplantation},
  author={Alan David Salama and Charles Dickson Pusey},
  journal={Nature Clinical Practice Nephrology},
Rituximab, a monoclonal antibody directed against the CD20 molecule found on pre-B cells and mature B cells (but not on plasma cells), was introduced in the late 1990s for the treatment of non-Hodgkin's lymphoma. Recently, this antibody has been used to treat autoimmune diseases, especially those associated with a prominent humoral component and with potentially pathogenic autoantibodies. Small cohort studies have indicated that rituximab could have an important role in the management of these… CONTINUE READING