Drug Insight: clopidogrel nonresponsiveness

  title={Drug Insight: clopidogrel nonresponsiveness},
  author={Paul A Gurbel and Udaya S. Tantry},
  journal={Nature Clinical Practice Cardiovascular Medicine},
Platelet reactivity to agonists and subsequent activation are important factors that affect the development of atherothrombosis and resultant ischemic events. Pharmacologic intervention with clopidogrel and aspirin during acute coronary syndromes and percutaneous coronary intervention is considered the gold standard for attenuating platelet activation and aggregation. Despite significant benefits reported with dual antiplatelet treatment in major clinical trials, the occurrence of adverse… CONTINUE READING
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