Drug Insight: cabergoline and bromocriptine in the treatment of hyperprolactinemia in men and women
@article{Colao2006DrugIC, title={Drug Insight: cabergoline and bromocriptine in the treatment of hyperprolactinemia in men and women}, author={Annamaria Colao and Antonella di Sarno and Ermelinda Guerra and Monica De Leo and Alberto Mentone and Gaetano Lombardi}, journal={Nature Clinical Practice Endocrinology \&Metabolism}, year={2006}, volume={2}, pages={200-210} }
Prolactinoma is the most frequent pituitary tumor histotype. Men generally have macroadenomas whereas women generally have microadenomas. The major objectives of treating prolactinomas are to suppress excessive hormone secretion and its clinical consequences, to remove the tumor mass while preserving the residual pituitary function, and possibly to prevent disease recurrence or progression. Primary therapy of prolactinomas is based on use of dopamine-receptor agonists. Bromocriptine induces…
60 Citations
Cabergoline for the treatment of bromocriptine-resistant invasive giant prolactinomas
- Medicine, PsychologyEndocrine
- 2018
Data of this retrospective study demonstrate that cabergoline is an excellent option for the treatment of patients with bromocriptine-resistant IGPs.
Evaluation of therapy with cabergoline in men with macroprolactinoma
- Medicine, Biology
- 2016
The administration of cabergoline to patients with macroprolactinoma is effective in reaching PRL level nor‐ malisation as well as in tumour size reduction, and therapy with caberg Caroline led to remission of headaches, visual acuity correction, and a significant improvement in libido and erection in all patients.
Clinical management of difficult to treat macroprolactinomas
- MedicineExpert review of endocrinology & metabolism
- 2019
The management of DA-resistant prolactinomas requires a multidisciplinary approach by an expert team and genetic screening for multiple endocrine neoplasia type 1 (MEN1) syndrome is actively discussed in a case-by-case approach.
Cabergoline versus bromocriptine for the treatment of giant prolactinomas: A quantitative and systematic review
- MedicineMetabolic Brain Disease
- 2018
Based on analysis, CAB is significantly better than BRC in normalizing PRL levels in patients, especially males, with giant prolactinomas, and both drugs are comparably effective for patients of both genders.
Effect of dopaminergic drug treatment on surgical findings in prolactinomas
- MedicinePituitary
- 2010
It is found that patients exposed to BROM for at least 1 month are more likely to have tumor fibrosis than patients that are untreated or treated with CAB.
Efficacy and Cerebrospinal Fluid Rhinorrhea after Cabergoline Treatment in Patients with Bioactive Macroprolactinoma
- Medicine, BiologyCancers
- 2021
Predicting dopamine agonist resistance in patients with macroprolactinoma is essential for clinicians to prevent treatment failure and subsequent complications such as medication-induced cerebrospinal fluid (CSF) rhinorrhea and hypopituitarism was independently associated with an increased risk of cabergoline resistance and CSF rhinnorhea.
Physiological Study of Some Hormonal Parameters in Infertile Hyperprolactinemic Women in Pre and Post-Treatment with Cabergoline and Bromocriptine
- Medicine, Biology
- 2012
Hyperprolactinemia associated with increased and decreased in some hormonal parameters and the dopamine agonist agents are effective in correcting the disturbance in these parameters.
Prolactinoma: Diagnosis, Treatment, and Follow-up (A Review Article)
- Medicine
- 2012
Since misdiagnosis of prolactinoma can cause mistreatment with costly drugs, precise evaluation, accurate diagnosis, understanding indications of treatment, duration of treatment and follow up are of high importance.
Gender differences in macroprolactinomas: study of clinical features, outcome of patients and ki-67 expression in tumor tissue.
- MedicineFrontiers of hormone research
- 2010
This is the first study focused in macroprolactinomas that shows that they are clinically and biologically more aggressive in men, and testosterone could be a source for E2 in situ aromatization giving male tumors an advantage in cell proliferation.
The Chance of Permanent Cure for Micro- and Macroprolactinomas, Medication or Surgery? A Systematic Review and Meta-Analysis
- MedicineFront. Endocrinol.
- 2018
Patients with prolactinomas can consider transsphenoidal surgery as an alternative first-line treatment strategy after receiving primary surgical intervention and administration of DAs should be considered based on the postoperative PRL level to achieve the best long-term remission rate.
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